Clinical Trials Methods for Evaluation of Potential Reduced Exposure Products
نویسندگان
چکیده
منابع مشابه
Clinical trials methods for evaluation of potential reduced exposure products.
Potential reduced exposure products (PREPs) to tobacco toxicants may have promise in reducing tobacco-related morbidity or mortality or may promote greater harm to individuals or the population. Critical to determining the risks or benefits from these products are valid human clinical trial PREP assessment methods. Such an assessment involves determining the effects of these products on biomark...
متن کاملMethods to assess potential reduced exposure products.
The availability of tobacco products purported to reduce toxin exposure or potentially reduce health risks necessitates the development of methods and identification of biomarkers that can be used to assess these products. These assessments occur on multiple levels and stages, from identifying constituents in the tobacco products and smoke, to human exposure and health effects trials, to postma...
متن کاملEvaluation of Clinical Trials
In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...
متن کاملTobacco specific nitrosamines and potential reduced exposure products for smokers: a preliminary evaluation of Advance.
OBJECTIVE To develop a method for evaluating the carcinogen delivery of potential reduced exposure products (PREPs) like Advance, a PREP marketed to reduce smokers' exposure to one tobacco specific nitrosamine (TSN), NNK, a potent lung carcinogen. DESIGN, SETTING, AND PARTICIPANTS Latin square ordered, three condition, outpatient, crossover design with 12 smokers of light or ultra-light cigar...
متن کاملTobacco specific nitrosamines and potential reduced exposure products for smokers: a preliminary evaluation of AdvanceTM
Objective: To develop a method for evaluating the carcinogen delivery of potential reduced exposure products (PREPs) like AdvanceTM, a PREP marketed to reduce smokers’ exposure to one tobacco specific nitrosamine (TSN), NNK, a potent lung carcinogen. Design, setting, and participants: Latin square ordered, three condition, outpatient, crossover design with 12 smokers of light or ultra-light cig...
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ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2009
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-09-0654